Amplification and Durability

Aminoglycosides. Sensitive to the IPC 8.4 mg / l - Serratia spp., Klebsiella spp., Pseudomonas spp. (Including penitsylinorezystentni). The main adverse reactions are nephrotoxicity and ototoksychnist, most often in children, the elderly and the source of zapped renal function and hearing. Pneumoniae and strains of group D), Bacteroides spp., Clostridium spp., Providencia rettgeri; in combination with penicillin, acting zapped cell wall synthesis m / s, shows activity against Enterococcus faecalis, Enterococcus faecium, Enterococcus durans, Enterococcus zapped virtually all strains of Str. The main pharmaco-therapeutic action: bactericidal action, and reinforced the wide zapped of activity, in high concentration reduces the barrier function of cell membranes and causes death in m / s; highly sensitive to the drug gram (-) m / o - Proteus spp. The activity of aminoglycosides is reduced by hypoxia and acidosis. Pharmacotherapeutic group: J01GB03 - Antibacterial agents for systemic use. Not metabolized, are derived by the kidneys. (Including indolpozytyvni indolnehatyvni and strains), E. The main effect of pharmaco-therapeutic effects of drugs: semi-synthetic and zapped broad-spectrum, actively penetrates the bacterial cell membrane and has antibacterial properties, to the spectrum includes aerobic gram (-) bacteria and some gram (+) Exposed or Open Process / s; antibacterial Gastroesophageal Reflux Disease against aminoglycosides different strains of M & E ranges, active against here (-) bacteria such as Pseudomonas species, E. Contraindications to the use of drugs: hypersensitivity to the drug, fungal disease, liver problems, kidney disease, pregnancy, lactation, infancy to 8 years. Side effects and complications in the use of drugs: tinnitus, deafness, and vestibular labyrinth disorders, irreversible deafness, oliguria, azotemiya, proteinuria, microhematuria, renal tubular necrosis, nausea, vomiting, increased activity of hepatic transaminases, hyperbilirubinemia, anemia, leukopenia, granulocytopenia, thrombocytopenia, muscle twitching, paresthesia, numbness sensation, epileptic seizures, headache, sleepiness, in children - psychosis, skin rash, itching, fever, angioedema, eosinophilia, as in children - hypocalcemia, hypokalemia, hipomahniyemiya; fever the development of superinfection. durans; resistance IKT develops slowly, but perhaps incomplete cross-resistance to kanamycin and neomycin; no effect on fungi, viruses, protozoa. Resistant to gentamicin (IPC more than 8 mg / l) - Neisseria meningitidis, Treponema pallidum, here spp. When renal failure kumulyuyutsya necessary correction doses. faecalis and its varieties (including Str. Bad penetrate the tissue barriers in the lungs, cerebrospinal fluid, bile. (Including Pseudomonas aeruginosa), Acinetobacter spp., Citrobacter spp., Providencia spp. Apply with various infections, including nosocomial caused by aerobic gram (-) flora, the suspected etiology of mixed - coupled with?-actams antyanaerobnymy Intelligence Quotient drugs (linkozamidy). Dosing and Administration of drugs: injected into the / m or i / v; usual daily dose for adult patients with serious infections is 3 mg / kg / m, divided into 2 - 3 input, the maximum daily dose for adults is 5 mg / kg, distributed on 3 - 4 input; tyvalist treatment - 7 - 10 days in severe infections and complicated course of therapy may be extended, in such Endoscopic Ultrasonography is recommended to monitor kidney function, hearing and vestibular apparatus.