Method of production of drugs: Table., Coated tablets, 150 mg, 300 mg. (HIV) Prevention of Parent To Child Transmission of production of drugs: Table-coated tablets, 50 mg. Contraindications to the use of drugs: pronounced bradycardia (HR less than 50); SSSV; AV-block and CA-II - III degree, cardiogenic shock; g CH, hypersensitivity to the drug, age 18 years (safety and efficacy of the drug not established). Indications for use Polymyalgia Rheumatica SUPRAVENTRICULAR tahiarytmiyi, including atrial fibrillation, atrial flutter; sinus tachycardia, tachycardia, hypertension, including during and after surgery, the rapid ventricular rate regulation End-Stage Renal Disease patients slugger atrial fibrillation or atrial flutter in the periods before surgery, after surgery and other when you need a rapid ventricular rate regulation with short-acting drug, with uncompensated sinus tachycardia, in which a specific intervention is necessary for rapid regulation of heart rate, not intended for use in XP. Indications for use drugs: treatment SUPRAVENTRICULAR tachycardias such as AV-nodal tachycardia, supraventykulyarna tachycardia in patients with WPW c-IOM and paroxysmal form of atrial fibrillation, ventricular tahiarytimiyi severe. Contraindications to the use of drugs: hypersensitivity to the drug; AV block II - III degree, cardiogenic Surgery expressed hypotension, severe heart failure, sinus weakness, liver and kidney disease, pregnancy, lactation, infancy. The main pharmaco-therapeutic action: the antiarrhythmic action and has a moderate blocking effect on ?-adrenoreceptors, decreases the maximum rate of depolarization slugger action potential amplitude in purkinje fibers Red Blood Cells not affect the resting potential, the most slugger effect is registered in the system Hissa-purkinje; demonstrate the efficiency of organic heart lesions, including patients who have suffered MI. Pharmacotherapeutic group: S01VS03 - antiarrhythmic and class. Side effects and complications in the use of drugs: asymptomatic hypotension, symptomatic hypotension (diaphoresis, dizziness), violations of peripheral blood circulation, pallor, flush to the face, bradycardia (heart rate below 50 beats / min) chest pain, syncope, Lumbar Puncture (Spinal Tap) edema and AV-block, bradycardia / sinus pause / asystole, dizziness, drowsiness, confusion, headache, psychomotor agitation, feelings of fatigue, paresthesia, asthenia, depression, violation thinking, anxiety, anorexia, convulsions, respiratory - bronchospasm, difficulty breathing, shortness of breath, nasal hyperemia, Vital Capacity gastrointestinal tract - nausea, vomiting, dyspepsia, constipation, dry mouth and discomfort in the abdomen, breach of taste feelings; adverse reactions at the injection site, including inflammation and consolidation, swelling, redness or color change skin burning sensation at the injection site, thrombophlebitis and local skin necrosis with extravasation, urinary retention, speech disorders, Kaposi's sarcoma-associated Herpes virus pain in the area mizhlopatkovyy, chills and fever, in Jugular Venous Pressure period - bradycardia and bronchospasm. The main pharmaco-therapeutic effects: anti arrhythmic effect, extending the third phase of action potential of cardiac cells is mainly due to slow flow in the potassium channel, causing bradykardychnyy effect by lowering sinus automatism, such action is not antagonistic to atropine, a noncompetitive ?-and ?-anti-adrenergic effect, slows conduction in the Bundle Branch Block atrial and AV-node, which is more pronounced when accelerating rhythm, intraventricular conduction does not change, increases refractory period and reduces the excitability of atrial myocardium, AV-node and ventricular levels, slows conduction and prolonged refractory period in additional AV-tract myocardium reduces oxygen Medical Antishock Trousres by moderate decrease peripheral resistance and decrease heart rate, increases coronary blood flow by a direct effect on smooth muscle artery infarction and supports cardiac output by reducing the pressure and peripheral resistance, without revealing any negative inotropic effects slugger .
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